- Sirloin Stockade
- Sister Superior
- Sister's Cafe
- Sisters of Charity BVM
- Sisters of Charity of St Augustine
- Sisters of Holy Cross OFC
- Sisters of Mercy Convent
- Sisters of St Francis of Assisi
- Sisters of St Joseph Convent
- Sisters of the Humility of Mary
- Site for Sore Eyes
- Site Services
- Sitel Corporation
- Six Figure Income
- Six Robblees
- Six States Distributors
- Size 5-7-9 Shop
- Size 5-7-9 Shops
- Sizes Unlimited Avenue
- Sizzler
- Sizzler Restaurant
- SJP Properties
- Skanska USA Building
- Skate City
- Skate World
- Skate Zone
- Skechers
- Skeffington's Formal Wear
- Ski Haus
- Ski Market
- Skill Creations
- Skilled Services Corporation
- Skills Development Services
- Skillsoft
- Skin Care
- Skin Care Center
- Skin Deep
- Skin Essentials
- Skin Solutions