- Southside Barber Shop
- Southside Cafe
- Southside Mini Storage
- Southtrust Bank
- Southtrust Bank NA
- Southtrust Mortgage Corporation
- Southview Apartments
- Southwest Airlines
- Southwest Airlines - Baggage Service Office
- Southwest Airlines - Cargo Operations Office
- Southwest Airlines - Marketing Office
- Southwest Airlines Cargo
- Southwest Airlines Reservations And Information
- Southwest Auto Sales
- Southwest Chiropractic
- Southwest Community Bank
- Southwest Electric
- Southwest Financial Services
- Southwest Funding
- Southwest Gas Corporation
- Southwest Key Program
- Southwest Land Title
- Southwest Mississippi Mental Health Complex
- Southwest Mississippi Regional Medical Center
- Southwest Securities
- Southwestern Bell
- Southwestern Bell Wireless
- Southwestern Eye Center
- Southwind Apartments
- Southwood Apartments
- Souvenir City
- Spa Nails
- Space
- Space Place
- Spaghetti Factory the Old
- Spahn & Rose Lumber
- Spanish Oaks Apartments
- Spanky's
- Spare Time Clubs