- Sutherlands Building Material
- Sutter Gould Medical Foundation
- Sutter Medical Group
- Suttles Truck Leasing
- Sutton Place Apartments
- Suwannee Medical Personnel
- Suwannee River Economic Council
- SVS Vision
- Swan Cleaners
- Swank Audio Visual
- Swanson Corporation
- Swap Shop
- Swarovski
- Swarovski Boutique
- Swatch
- Sweatshop
- Sweet Creations
- Sweet Expressions
- Sweet Factory
- Sweet Frog Yogurt
- Sweet Memories
- Sweet Pea
- Sweet Pea's
- Sweet Repeats
- Sweet Sensations
- Sweet Shop
- Sweet Shoppe
- Sweet Spot
- Sweet Temptations
- Sweet Things
- Sweet Tomatoes
- Sweet Tooth
- Sweet Treats
- Sweetbay Supermarket
- Sweets & Treats
- Sweets From Heaven
- Swett & Crawford
- Swift Cleaners
- Swift Transportation