- Schnucks Supermarkets
- Schoettler Tire
- Schoop's Hamburgers
- Schrader's Country Store
- Schuckmans Alternators & Starters
- Schuck's Auto Supply
- Schultz Electric
- Schuylkill Valley Sports
- Schwab Les Tire Centers
- Schwan's Ice Cream
- Schwan's Sales Enterprises
- Schwebel Baking
- Schwerman Trucking
- Schweser's
- SCI
- Science of Mind Center
- Scissor Hands
- Scissor Happy
- Scissor Shack
- Scissor Talk
- Scissor Wizard
- Scissor's Palace
- Scoop
- Scooter World
- Scooter's
- Score
- Score Educational Center
- Score Educational Centers
- Scoreboard
- Score-Service Corps of Retired Executives
- Scotch Fabric Care Services
- Scotland Yard
- Scotsman Ice Systems
- Scott & Associates
- Scott Cleaners
- Scott Construction
- Scott Electric
- Scott Petroleum Corporation
- Scott Valley Bank